In Vitro and In Silico Studies of Quercetin and Daidzin as Selective Anticancer Agents

Quercetin and daidzin are flavonoid glycoside type compounds that have been found in many plants nutraceuticals. This study aims to examine the vitro cytotoxic selectivity properties of quercetin on breast cervical cancers their molecular interaction stability epidermal growth factor receptor tyrosine kinase (EGFR-TK) by applying docking dynamics (MD) simulations. In anticancer activity was performed 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method cancer cell (T47D), cells (HeLa), Vero normal cells, while MD simulation were done using AutoDock Vina Amber18 package software, respectively. showed potent high both lines. Daidzin has a higher IC50 index than quercetin. Docking results prefer interact with (EGFR-TK). better score -9.6 kcal/mol. Also, more stable low RMSD RMSF values.